CD38 in Adenosinergic Pathways and Metabolic Re-programming in Human Multiple Myeloma Cells: In-tandem Insights From Basic Science to Therapy

Tumor microenvironments are rich in extracellular nucleotides that can be metabolized by ectoenzymes to produce adenosine, a nucleoside involved in controlling immune responses.Multiple myeloma, a plasma cell malignancy developed within a bone marrow niche, exploits adenosinergic pathways to customize the immune homeostasis of the tumor.CD38, a mul

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Evidence-based campaigning

Abstract Background When promoting public health measures, such as reducing smoking, there are many different approaches, for example providing information, imposing legal madelaine chocolate advent calendars restrictions, taxing products, and changing cultures.By analogy with evidence-based medicine, different approaches to campaigning for health

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